Targeted cisplatin
WebApr 12, 2024 · Three mechanisms define cisplatin’s direct involvement, demonstrating the chemo-resistant tumor cell phenotype: pre-target, on-target, and post-target resistance [20,21,22]. The first is characterized by reduced intracellular accumulation and increased cisplatin sequestration caused by GSH and other scavengers. WebThe discrepancy of surface receptors on cancerous and non-cancerous cells has been regarded as the mainstay of cancer-targeted therapy. However, due to the heterogeneity …
Targeted cisplatin
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WebThe structure of the [Pd 2 L 4 ⊃(cisplatin) 2](BF 4) 4 host–guest adduct has been confirmed by 1 H NMR spectroscopy, HR-ESMS and X-ray crystallography. Additionally we have … WebAbstract Cisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. ... Recently, AMs targeted to proteins have attracted wide attention in the fields of molecular biology, biotechnology, and biomedicine. 26-28 Haghighi et al. developed AMs that bind ...
WebJan 18, 2024 · As a target of cisplatin, GG dinucleotides are enriched 5–8 nt upstream of the 3′-end of the reads across all samples (Supplementary Figures 10 and 11 ), which is consistent with previous... WebFeb 3, 2024 · Introduction. In recent decades, cisplatin (cis-diamminedichloroplatinum II, or DDP), a classic platinum-based antitumor agent that exerts significant genotoxicity, has been extensively applied in clinical treatment and laboratory research 1.Because of its broad spectrum of anticancer activity, cisplatin is used to treat various solid tumors such as …
WebJun 30, 2013 · Targeted knockdown of NBK/BIK significantly reduced the proapoptotic effects of MLN4924/cisplatin, indicating that this BH3-only protein is a critical regulator of sensitivity to this combination (Fig. 5C and D). We are currently investigating the mechanisms that underlie the ability of MLN4924 and cisplatin to significantly increase … WebNiraparib (Zejula) may be used in some situations to treat ovarian cancer. In women with or without a BRCA gene mutation: Niraparib might be used as maintenance treatment for advanced ovarian cancer, where the cancer has shrunk with first-line chemotherapy containing cisplatin or carboplatin. In women with a BRCA gene mutation:
WebJan 13, 2011 · Here we report that targeted delivery of cisplatin in the form of a prodrug 1 using a NP delivery system can markedly improve its tolerability and efficacy in vivo. Our studies have broad implications for cancer therapy given the relatively ubiquitous use of … Proceedings of the National Academy of Sciences of the United States of ...
WebMethods. Twenty-five patients diagnosed with stage III/IV pyriform sinus squamous cell carcinoma treated with supradose, intra-arterial targeted cisplatin, and concomitant radiotherapy were analyzed for response rates, survival, pattern of failure, and function of the preserved organs. couple frame backgroundWebApr 14, 2024 · Non-Targeted Metabolomics Analysis of ABs Induced by Cisplatin and UV Light Exposure Since HK-2-cells-generated-Abs, both by cisplatin or upon UV light exposure, can induce apoptosis in HK-2 cells, the purpose of this work was to study their metabolome and therein find the molecular features which help us to unravel the mechanisms of that ... briana\u0027s hope worthington inWebJan 27, 2024 · Patients with locally advanced disease also elicited a better median OS with the triplet (n = 77) at 19.2 months compared with 13.7 months with the doublet (n = 41). Further, the median PFS was 9.3 months with the addition of nab-paclitaxel vs 7.6 months with gemcitabine and cisplatin alone. “At the end of the day, this study did not meet its ... couple fitness swagWebApr 11, 2024 · Testicular cancer, also known as testicular germ cell tumors (TGCT), is the most common type of cancer in young men. When treated with cisplatin, the tumor cells stop growing and die. This is ... briana\\u0027s hair spa frederick mdWebMay 1, 2024 · Targeted nanomedicine shows great promise in delivering cisplatin for maximizing efficacy while minimizing off-target toxicity. This article surveyed the recent progress and challenges of targeted nanomedicine in managing resistance and toxicity of cisplatin in both fundamental and clinical aspects. briana\\u0027s jewel salon west mifflinWebThe cellular uptake of cisplatin and its targets. Reprinted with permission. 1 As seen in Figure 1, once inside the cell, cisplatin has a number of possible targets: DNA; RNA; sulfur-containing enzymes such as metallothionein and glutathione; and mitochondria. couple friendly hotels hourly basisWebThe discrepancy of surface receptors on cancerous and non-cancerous cells has been regarded as the mainstay of cancer-Targeted therapy. However, due to the heterogeneity of tumor cells and the insufficient levels of receptors on the tumor cell surface, the success of cancer cell-Targeted therapies is largely limited. briana\u0027s hair spa frederick md