Klf2 and precursor exhausted t cells
WebJun 16, 2014 · KLF2 is a zinc-finger transcription factor that has a documented role in controlling naive T-cell migration patterns (12–14).Its expression is promoted by Foxo1, a PKB-regulated transcription factor that has also been reported to control T-cell circulation (9, 10).Moreover, Foxo1 and Foxo3 promote Treg development and function; mice lacking … WebCytotoxic T cell immunity in response to chronic infections and tumours is maintained by a specialized population of CD8+T cells that exhibit hallmarks of both exhausted and …
Klf2 and precursor exhausted t cells
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WebSep 20, 2024 · These data suggest that TM cells in the blood can become more exhausted over time despite anti–PD-1 treatment, but ultimately the highest levels of exhaustion were in the tumor. We next quantified the extent to which the transcripts enriched in the TM component relative to the non-TM component correlated across patient samples. WebMar 1, 2024 · KLF2, a member of the Kruppel-like factor family, has diverse roles in the immune system, and in particular plays a critical role in controlling migration of T (and …
WebJul 20, 2006 · a, b, Thymocytes from Klf2 +/-or Klf2-/-FLCs were transferred into C57BL/6.SJL hosts and labelled with BrdU for 14 days. The percentage (a) and absolute … WebJul 17, 2009 · KLF2 transcription-factor deficiency in T cells results in unrestrained cytokine production and upregulation of bystander chemokine receptors The transcription factor KLF2 regulates T cell trafficking by promoting expression of the lipid-binding receptor S1P(1) and the selectin CD62L.
WebJul 18, 2024 · One hallmark of exhausted T cells is the increased appearance on their surface of checkpoint proteins like PD-1 and CTLA-4, which can cause those T cells to stand down. Immune checkpoint inhibitors block these checkpoint proteins and, in so doing, can rev up the immune response against tumors. WebImmunological Genome Project
WebThe Impact of KLF2 Modulation on the Transcriptional Program and Function of CD8 T Cells Gavin C. Preston 1, Carmen Feijoo-Carnero, Nick Schurch2, Victoria H. Cowling, Doreen A. Cantrell1* 1 Department of Cell Signalling & Immunology, College of Life Sciences, University of Dundee, Dundee, United Kingdom, 2 Data Analysis Group, Department of
WebNov 19, 2010 · Kruppel-like factor 2 (KLF2) is a transcription factor which has been shown to be a critical regulator of T lymphocyte quiescence and trafficking. KLF2 is highly expressed in naïve CD8 T cells but its expression is transcriptionally downregulated in effector cytotoxic T lymphocytes (CTL). chevron corporation abu dhabigood things god gives usWebMay 19, 2024 · Exposure to chronic infection or malignant tumors triggers the differentiation of functionally impaired, so-called exhausted T cells. In this issue of Immunity, Beltra et al. reveal a multi-step developmental process that defines how T cells transition from proliferating progenitors into terminally differentiated exhausted T cells. chevron corp bakersfieldWeb(1). We and others have shown that KLF2 is critical for T-cell trafficking through regulation of the genes encoding sphingosine-1 phosphate receptor 1 (S1Pr1) and CD62L (L … chevron corporate affairs advisorWebOct 29, 2024 · This lung cancer–specific T cell dysfunction program was established early during priming in the mediastinal lymph node and was characterized by robust proliferation but a failed up-regulation of effector and exhausted T cell characteristics. good things grocery lockhartWebExhausted CD8 + T cells in the setting of chronic viral infection exhibit reduced TCR-activation of the Akt–mTOR pathway, resulting in increased transcriptional activity of FOXO1, where PD-L1-blockade restores the mTOR activity [118].FOXO1 in turn directly activates the transcription of PD-L1, suggesting that a positive feedback loop of PD … chevron corporate bonds quoteWebOct 1, 2024 · Terminally exhausted T cells (TEx) have been shown to express high levels of IC receptors such as PD1 and TIM3 and low TCF1 , while progenitor exhausted T cells (TPEx) are PD1 + , TIM3and display ... chevron corporate giving program