Hipk2 relocalization

Author: tblr

August undefined, 2024

WebbControl of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR. (Q39974501) From Wikidata. Jump to navigation ... Webb1 juni 2013 · HIPK2 (homeodomain-interacting protein kinase-2) binds to and phosphorylates, at Ser and Thr residues, a large number of targets involved in cell division and cell fate decision in response to different physiological or stress stimuli. …

Integration of stress signals by homeodomain interacting protein …

WebbHIPK2 relocalization from the nucleus to the cytoplasm, in- In contrast, in neoplastically transformed cells as well as in hibiting p53 apoptotic function, whereas HIPK2 overexpres- embryonic cells, the constitutive expression of HMGA pro- sion re-established HIPK2 … Webb12 dec. 2016 · High-mobility group A1 inhibits p53 by cytoplasmic relocalization of ; ... March 2007 693 High-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2 Giovanna Maria Pierantoni, … safe space for bbc lovers

HIPK family kinases bind and regulate the function of the CCR4 …

Webb16 apr. 2010 · HIPK2 is considered a nuclear S/T kinase that binds and phosphorylates a still enlarging body of targets involved in the regulation of cell survival and proliferation during development and in response to genotoxic damage or hypoxia [1–4]. WebbCytoplasmic relocalization of HIPK2 induced by HMGA1 overexpression is a mechanism of inactivation of p53 apoptotic function that the authors believe to be novel. High-mobility group A1 (HMGA1) overexpression and gene rearrangement are frequent events in … Webb15 mars 2024 · There were three expression patterns of HIPK2 including positive nucleus, positive both nucleus and cytoplasm, and only positive cytoplasm. The main positive location of normal epithelium cells... safe sounds personal alarms

Updates on HIPK2: a resourceful oncosuppressor for …

Role of HIPK2 in kidney fibrosis - Kidney International Supplements

Webb4 apr. 2024 · HIPK2 is a serine/threonine kinase, located in the nucleus, that was initially found to be able to phosphorylate p53 at Ser46 to promote apoptosis; it has been widely studied. It has been reported that HIPK2 can simultaneously regulate TGF-β/Smad3, Wnt/β-catenin, Notch and NF-κB pathways in the kidney to initiate inflammation and … Webb21 mars 2024 · HIPK2 (Homeodomain Interacting Protein Kinase 2) is a Protein Coding gene. Diseases associated with HIPK2 include Keratoacanthoma and Encephalopathy, Neonatal Severe, Due To Mecp2 Mutations.Among its related pathways are Gene … safe sovereign wealth fundWebb7 aug. 2003 · HIPK2 is evolutionary conserved, contains an NH 2 -terminal kinase domain and localizes to nuclear speckles, raising the question whether ( a) HIPK domains form an independent subnuclear compartment and ( b) whether HIPK2-mediated p53 … safespace bed

"Webbalytic activity of HIPK2, and the consequent determination of cell fates (Fig. 1). In this review we will focus on the determina-tion of cell fate—cell death or survival—by differential states of diverse HIPK2 post-translational modiﬁcations (termed the “HIPK2 … " - Hipk2 relocalization

Hipk2 relocalization

WebbHere we describe a mechanism through which HMGA1 inhibits p53-mediated apoptosis by counteracting the p53 proapoptotic activator homeodomain-interacting protein kinase 2 (HIPK2). We found that HMGA1 overexpression promoted HIPK2 relocalization in the … WebbHomeodomain-interacting protein kinase 2 (HIPK2) is a tumor suppressor mediating growth suppression and apoptosis upon genotoxic stress through phosphorylation of p53 at Ser46. Here we show that Src phosphorylates HIPK2 and changes its subcellular localization. Using mass spectrometry we identified 9 Src-mediated Tyr-phosphorylation …

Did you know?

WebbFigure 3 Contribution of p53 phosphorylation at Ser46 to HMGA1/HIPK2-induced BAX promoter activity. (A) Western blot analysis of the indicated protein in WT p53– carrying HCT116 cells 48 hours after infection at the indicted MOI. (B) The same cells analyzed in A were treated with UV light at 50 J/m2. At 5 and 12 hours after UV light irradiation, the …

WebbIt was recently shown that p53-dependent apoptosis is promoted by homeodomain-interacting protein kinase-2 (HIPK2), ... This relocalization promotes several p53 post-translational modifications, which enhance its trans-activation activity (16. Salomoni P. Pandolfi P.P. Cell. 2002; 108: 165-170. Webb25 apr. 2013 · Dysregulation of HIPK2 can result in increased proliferation of cell populations as it occurs in cancer or fibrosis. We discuss various models that could explain how inappropriate expression, modification, or localization of HIPK2 can be a …

WebbHere we describe a mechanism through which HMGA1 inhibits p53-mediated apoptosis by counteracting the p53 proapoptotic activator homeodomain-interacting protein kinase 2 (HIPK2). We found that HMGA1 overexpression promoted HIPK2 relocalization in the … Webb30 juli 2024 · The HIPK2 kinase domain, which was crystallized in the active conformation, was stabilized through active loop phosphorylation. The authors further characterized the manner in which CX-4945 engaged the active site of HIPK2, as well as structural …

Webb15 feb. 2024 · Here we describe a mechanism through which HMGA1 inhibits p53-mediated apoptosis by counteracting the p53 proapoptotic activator homeodomain-interacting protein kinase 2 (HIPK2). We found that HMGA1 overexpression promoted HIPK2 relocalization in the cytoplasm and inhibition of p53 apoptotic function, while …

Webb1 nov. 2013 · Retraction Free access 10.1172/JCI73730 High-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2 Giovanna Maria Pierantoni, Cinzia Rinaldo, Marcella Mottolese, Anna Di Benedetto, Francesco Esposito, Silvia Soddu, and Alfredo Fusco Published November 1, 2013 - More info View PDF … safe space heaters amazonWebb1 apr. 2014 · The intracellular localization of HIPK2 can be regulated by acetylation of lysines contained in NLS1 (de la Vega et al., 2012) or by cytoplasmic relocalization of HIPK2 by increased expression of high-mobility group A1 protein (Pierantoni et al., … safe space heater for grow boxWebb15 apr. 2016 · The U.S. Department of Energy's Office of Scientific and Technical Information safe space footscrayWebb30 juni 2010 · Here, we show that Bcl-2 is a gene regulated by the HMGA1-p53-HIPK2 complex and that HMGA1 is able to abolish the repression promoted by p53 on Bcl-2 expression. Subsequently, we looked for other components of this multiprotein … safe space heater automatic shut offWebb25 juli 2011 · Hipk2 is a recently identified serine/threonine nuclear kinase that is highly conserved in mammalian organisms. Hipk2 acts as a multi-functional transcriptional regulator and corepressor that... safe space for studentsWebb19 okt. 2005 · In addition, HIPK2 exhibited a diffused localization pattern in the nucleoplasm with the relocalization of SENP1 (Fig. 3, arrow). HIPK2 desumoylation as the result of SENP1's activity was evaluated with Western blot analysis following … safe space bedroomWebb21 mars 2024 · HIPK2 is a target for SENP1 desumoylation regulated by the cytoplasmic-nuclear shuttling of SENP1. HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function. HIPK2 participates in the TGF-beta … safe space heater for home