Dihydrosphingomyelin
WebSep 1, 2024 · dihydrosphingomyelin. Definition from Wiktionary, the free dictionary. Jump to navigation Jump to search. English Etymology . dihydro + sphingomyelin. Noun . dihydrosphingomyelin (plural dihydrosphingomyelins) (organic chemistry) Any derivative of a sphingomyelin in which the double bond of the sphingosine moiety has been … WebApr 12, 2024 · 18 Johnston et al., Characterization of the drug retention and pharmacokinetic properties of liposomal nanoparticles containing dihydrosphingomyelin, Biochimica et Biophysica Acta 1768 (2007) 19 Cipolla et al., Modifying the Release Properties of Liposomes Toward Personalized Medicine, Journal of Pharmaceutical …
Dihydrosphingomyelin
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WebAug 13, 2024 · The hydration properties of the lipid bilayer interface are important for determining membrane characteristics. The hydration properties of different lipid bilayer species were evaluated using the solvent sensitive fluorescence probe, 6-lauroyl-2-dimethylamino naphthalene (Laurdan). Sphingolipids, D- erythro -N-palmitoyl … WebIn contrast, Ca (2+) induces relatively minor dehydration around the amide groups of dihydrosphingomyelin and a slight enhancement of direct lipid-lipid interactions. Temperature-dependent studies reveal that 0.2 M Ca (2+) increases the transition temperature T (m) from 31.6 +/- 1.0 degrees C to 35.7 +/- 1.1 degrees C for SM and from …
WebJun 2, 2024 · 3101 Background: FF-10850 (liposomal topotecan) was developed using a unique dihydrosphingomyelin-based carrier to enhance tumor drug delivery and retention, leading to improved efficacy and safety. Preclinical studies demonstrated superior anti-tumor activity with less myelosuppression compared to topotecan, with a pharmacokinetic (PK) … WebJul 30, 2010 · Dihydrosphingomyelin (DHSM), the most abundant dihydrosphingolipid in our cell lines, induces formation of rigid gel-like domains interspersed in the liquid-ordered phase of model membranes. As a consequence of DHSM accumulation, membrane microdomains are formed with sufficient rigidity to hinder gp41 fusion peptide insertion.
WebDihydrosphingomyelin is a lipid that exhibits a gel–fluid transition with a melting point of approximately 47 °C. Phase transition also takes place in a subsequent cooling process, … WebMay 1, 2003 · The thermotropic properties of binary mixtures of D-erythro-n-palmitoyl-dihydrosphingomyelin (16:0-DHSM), D-erythro-n-palmitoyl-sphingomyelin (16:0-SM), cholesterol, lathosterol, and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) were studied by differential scanning calorimetry.Addition of sterol to 16:0-DHSM and 16:0-SM …
WebDihydrosphingomyelin (DHSM), the most abundant dihydrosphingolipid in our cell lines, induces formation of rigid gel-like domains interspersed in the liquid-ordered phase of model membranes. As a consequence of DHSM …
WebChronic stress is a major risk factor for several human disorders that affect modern societies. The brain is a key target of chronic stress. In fact, there is growing evidence indicating that exposure to stress affects learning and memory, decision george northupWeb2 days ago · In patients, early investigations reported an increase of Cer in liver and plasma of NAFL and NASH patients [15], [16], while recently publications only report increases in dihydrosphingolipids, - dhCer and dihydrosphingomyelin (dhSM) - in liver [17], [18] and plasma [19], [20]. The lack of representation of the full disease spectrum of NAFLD ... george northwest glass indianaWebdihydrosphingomyelin from bovine brain and chicken egg sphingolipid samples. In contrast to most previous literature reports that used LC/MS, we reported a substantial propor-tion of dihydrosphingomyelin species in bovine brain, in addition to the commonly reported sphingomyelin species. The significant proportion of DSM species was … christian b millerWebApr 3, 2024 · Increasing the siRNA knockdown efficiency of lipid nanoparticles by morphological transformation with the use of dihydrosphingomyelin as a helper lipid. Masahiro Hashimoto, Sei Yonezawa, Song Furan, Chiori Nitta, Noriyuki Maeda, Koji Tomita, Ayano Yokouchi, Hiroyuki Koide, Tomohiro Asai. christian b newsWebFeb 15, 2006 · Both a substantial enrichment of the unusual sphingolipid dihydrosphingomyelin and a loss of viral infectivity upon inhibition of sphingolipid biosynthesis in host cells are reported, establishing a critical role for this lipid class in the HIV replication cycle. Intriguingly, the overall lipid composition of native HIV membranes … george northwood instagramWebSaturated form of sphingomyelin. Anti-HIV potential. For use in sphingolipid-related and lipid bilayer studies. See similar compounds. christian b mark williams thomasWebDihydrosphingomyelin Definition. (organic chemistry) Any derivative of a sphingomyelin in which the double bond of the sphingosine moiety has been hydrogenated. christian blunt