Circular rnas in toxicology
WebNov 23, 2024 · Circular RNAs (circRNAs) are a type of closed, long, non-coding RNAs, which have attracted significant attention in recent years. CircRNAs exhibit unique … WebMar 19, 2024 · Wesselhoeft et al. find that exogenous circular RNAs are able to bypass RNA sensors, thereby avoiding antiviral defense induction upon cellular entry. They report that nanoformulated, synthetic protein-coding circRNA can be translated in mouse tissues, providing evidence for the potential of circRNA as a vector for therapeutic gene expression.
Circular rnas in toxicology
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WebFeb 6, 2015 · INTRODUCTION. Circular RNAs are found in all kingdoms of life, appearing for example as genomes of viroidal plant pathogens and of the hepatitis delta virus (HDV) (), or as spliced tRNA and rRNA introns and as rRNA processing intermediates in archaea (3, 4).Furthermore, circRNAs are formed in the life cycle of bacterial and eukaryal group I … WebSubsequently, we generated the smoking-related endogenous RNAs (ceRNA) regulatory network through lncRNA–miRNA and miRNA–mRNA pairs. First of all, we predicted the potential miRNAs for smoking-related lncRNAs (miRcode) and then intersected with those miRNAs expressed in bladder tissues, followed by predicted mRNAs for these overlaps …
WebMar 9, 2024 · circRNAs are a new type of regulatory RNA that are widely expressed in eukaryotic cells and participate in a multitude of biological processes. Unlike linear RNAs with a 5′ cap and 3′ tail... WebJul 3, 2024 · Highly abundant exonic circular RNAs can cause the overall gene-level RPKM measurements to remain high after RNase R treatment, as is the case with the RNF13 gene that generates many circular RNAs. However, no exonic circular RNAs were detected from the majority (∼61%) of RNase R resistant protein-coding gene loci ( Supplementary …
WebMar 3, 2024 · One interesting aspect of circular RNAs is their translation into proteins. We previously discovered that circular RNA without a stop codon can be translated into long … WebA liver fibrosis rat model was established by intratracheal perfusion of NiONPs twice a week for 9 weeks. Whole-transcriptome sequencing was applied to obtain expression profiles of mRNAs, long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs) in the model rat and control liver tissues.
WebOct 25, 2024 · Department of Toxicology, Hebei Medical University, Shijiazhuang, China. Hebei Key Laboratory of Environment and Human Health, Hebei Province, Shijiazhuang, China. Correspondence. Huicai Guo, Department of Toxicology, School of Public Health, Hebei Medical University, 361 East Zhongshan Road, Shijiazhuang, Hebei Province …
WebMay 25, 2024 · Circular RNA (circRNA) is a new type of noncoding RNA that can form closed continuous loop structures with covalently joined 3′- and 5′-ends, which is in … flughafen thessaloniki transferWebApr 4, 2024 · Increasing researches revealed that circular RNAs (circRNAs) can control apoptosis. However, it is still unclear whether and how circRNAs are critical for regulating ADSCs apoptosis. In this study, we utilized in vitro model in which ADSCs were cultivated with normal glucose (NG) (5.5 mM) or high glucose (HG) (25 mM) medium, respectively, … greenerd hydraulic pressWebOct 25, 2024 · Based on circRNA and mRNA expression profiles, we illustrated RNA expression signature changes during DOX-induced cardiotoxicity; mechanism … flughafen tokio hndWebCircular RNAs play a role in Alzheimer disease pathogenesis They also performed additional analyses to demonstrate that the expression of circRNA were independent of … flughafen tobagoWebMay 25, 2024 · Cyclosporin A (CsA) is a well-known and effective drug that is commonly used in autoimmune diseases and allotransplantation. However, kidney toxicity and cardiotoxicity limit its use. Circular RNAs (circRNAs) play a crucial role in disease, especially cardiovascular disease. flughafen thessaloniki mapsWebApr 3, 2024 · Here, we systematically identified over 11,039 circRNAs expressed in vulnerable dopamine and pyramidal neurons laser-captured from 190 human brains and … flughafen texasflughafen thessaloniki abflug aktuell